Proprietary extract powered by
trans-e-viniferin and OPCs

In nature, survival depends on the evolution of strong defenses. The skin, vines and stems of grapes and some berries produce antioxidative and antimicrobial compounds that protect against pathogens and stress, such as UV irradiation. These natural defenses may have multiple benefits for human health and longevity.

Reverse-Vine® is a proprietary extract from a blend of red wine, grape cluster stems, and grapevine. It contains high levels of trans-resveratrol, a natural polyphenol and phytoalexin, a substance that helps plants defend against invading microbes. Reverse-Vine also has oligomeric proanthocyanidins (OPCs) and trans-e-viniferin, a resveratrol derivative that plays an important role in plant healing.

In addition to its antioxidant properties, trans-resveratrol regulates the gene expression of anti-oxidative enzymes, including superoxide dismutase (SOD), in human cells found throughout layers of skin as well as the vasculature.  SOD neutralizes free radicals that can prematurely age skin and helps promote the repair and production of healthy skin cells.

Research Supports Antioxidant Benefits

In vitro research shows that Reverse-Vine protected human cells exposed to oxidation, including a 25% increase in SOD activities. Reverse-Vine was 7% more effective than resveratrol alone and 44% more effective than the control group.

Reverse-Vine also showed superior activation of sirtuin 1 (SIRT1), an enzyme reported to regulate the metabolism and the lifespan of cells. This gene is believed to have a profound effect on animal lifespan, as studies have shown that animals with the SIRT-1 gene activated live, on average, as much as 40 percent longer than their counterparts.

Superior SIRT-1 Longevity Gene Activation

Health Applications

We believe the best health solutions are found in nature. For more than three decades Certified Nutraceuticals has discovered, developed and manufactured naturally bioactive and bioavailable ingredients that support a range of health needs.

Joint Health

Healthy Aging

Brain & Cognitive



Immune Health

Beauty from

Animal Health

DISCLAIMER: The information provided on this website is intended for educational purposes only. The educational material contained in this site is based on a careful analysis of the scientific literature and the experience of the Certified Nutraceuticals Sciences team. Our ingredients are cutting edge science and knowledgeable scientists have differing views as to its benefits and safety. We urge each prospective client to become educated about our ingredients and to consult their own experts prior to using any products that are true Anti-Aging, Health Mobility, Beauty dietary supplements.

These products are not intended to diagnose, treat, cure, or prevent any disease.

© Certified Nutraceuticals Inc. All rights reserved. | Website by blue media marketing, Inc.